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Symbol Name ID |
Kras
Kirsten rat sarcoma viral oncogene homolog MGI:96680 |
| Darker colors indicate more annotations |
| Human Phenotypes | Gastrointestinal hemorrhage |
Aganglionic megacolon |
Neoplasm of the rectum |
Hereditary nonpolyposis colorectal carcinoma |
Colon cancer |
Intestinal polyposis |
Intestinal pseudo-obstruction |
Neoplasm of the stomach |
Stomach cancer |
Constipation |
Intermittent diarrhea |
Nausea and vomiting |
Functional abnormality of the gastrointestinal tract |
Functional intestinal obstruction |
Neoplasm of the liver |
Hepatocellular carcinoma |
Abnormality of the gastrointestinal tract |
| Disease(s) Associated with KRAS | |||||||||||||||||
| cardiofaciocutaneous syndrome | |||||||||||||||||
| colorectal cancer | |||||||||||||||||
| Lynch syndrome | |||||||||||||||||
| multiple myeloma | |||||||||||||||||
| oculoectodermal syndrome | |||||||||||||||||
| pancreatic cancer | |||||||||||||||||
| stomach cancer |
| Mouse Phenotypes | abnormal intestinal goblet cell morphology |
abnormal colon goblet cell morphology |
abnormal pancreatic acinar cell morphology |
abnormal pancreatic duct morphology |
abnormal intestine morphology |
abnormal intestinal epithelium morphology |
abnormal large intestine crypts of Lieberkuhn morphology |
absent Paneth cells |
abnormal colon morphology |
submandibular gland hyperplasia |
increased esophageal papilloma incidence |
increased mouth tumor incidence |
increased oral papilloma incidence |
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| Availability | Mouse Genotype | |||||||||||||
| Krastm2Tyj/Kras+ | ||||||||||||||
| Krastm3Tyj/Kras+ | ||||||||||||||
| Krastm4Tyj/Kras+ Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ (conditional) |
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| Krastm1.1Khai/Kras+ Tg(Fabp1-cre)1Jig/0 (conditional) |
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| Krastm4Tyj/Kras+ Ptf1atm1.1(cre)Cvw/Ptf1a+ (conditional) |
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| Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Fabp1-cre)1Jig/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(MMTV-cre)4Mam/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Pdx1-cre)6Tuv/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(Pbsn-cre)20Fwan/0 (conditional) |
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| Krastm4Tyj/Kras+ Tg(KRT14-cre/ERT)20Efu/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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